EzCatDB: D00031

DB codeD00031
CATH domainDomain 13.40.50.1770Catalytic domain
Domain 23.40.50.720Catalytic domain
E.C.1.4.1.1
CSA1pjb
MACiEM0067

CATH domainRelated DB codes (homologues)
3.40.50.1770M00161
3.40.50.720S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00457,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00032,D00033,D00034,D00035,D00037,D00048,D00071,D00476,D00481,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00247,T00408,T00414,D00827,D00262,D00274,D00275,M00035,T00109

Enzyme Name
Swiss-protKEGG

O52942
Protein name
alanine dehydrogenase
AlaDH
L-alanine dehydrogenase
NAD+-linked alanine dehydrogenase
alpha-alanine dehydrogenase
NAD+-dependent alanine dehydrogenase
alanine oxidoreductase
NADH-dependent alanine dehydrogenase
SynonymsAlanine dehydrogenase
EC 1.4.1.1

KEGG pathways
MAP codePathways
MAP00430Taurine and hypotaurine metabolism
MAP00720Reductive carboxylate cycle (CO2 fixation)

Swiss-prot:Accession NumberO52942
Entry nameO52942_PHOLP
Activity
Subunit
Subcellular location
Cofactor


SubstratesProducts
KEGG-idC00041C00001C00003C00022C00014C00004C00080
CompoundL-AlanineH2ONAD+PyruvateNH3NADHH+
Typeamino acidsH2Oamide group,amine group,nucleotidecarbohydrate,carboxyl groupamine group,organic ionamide group,amine group,nucleotideothers
1pjbA01Unbound
UnboundUnboundUnboundUnbound
1pjcA01Unbound
UnboundUnboundUnboundUnbound
1sayA01Unbound
UnboundBound:PYRUnboundUnbound
1pjbA02Unbound
UnboundUnboundUnboundUnbound
1pjcA02Unbound
Bound:NADUnboundUnboundUnbound
1sayA02Unbound
UnboundUnboundUnboundUnbound

Active-site residues
resource
literature [2]
pdbCatalytic residues
1pjbA01LYS 74;HIS 95;GLU 117
1pjcA01LYS 74;HIS 95;GLU 117
1sayA01LYS 74;HIS 95;GLU 117
1pjbA02ASP 269
1pjcA02ASP 269
1sayA02ASP 269

References for Catalytic Mechanism
ReferencesSectionsNo. of steps in catalysis
[2]p.563-564, Fig.33

references
[1]
CommentsX-ray crystallography
PubMed ID7896761
JournalJ Biochem (Tokyo)
Year1994
Volume116
Pages995-1000
AuthorsSawa Y, Tani M, Murata K, Shibata H, Ochiai H
TitlePurification and characterization of alanine dehydrogenase from a cyanobacterium, Phormidium lapideum.
Related PDB1pjc
[2]
CommentsX-ray crystallography
PubMed ID9665169
JournalNat Struct Biol
Year1998
Volume5
Pages561-7
AuthorsBaker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW
TitleAnalysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.
Related PDB1say,1pjb
[3]
PubMed ID10611473
JournalFEBS Lett
Year1999
Volume464
Pages1-8
AuthorsJackson JB, Peake SJ, White SA
TitleStructure and mechanism of proton-translocating transhydrogenase.
[4]
PubMed ID10385325
JournalNat Biotechnol
Year1999
Volume17
Pages588-92
AuthorsHols P, Kleerebezem M, Schanck AN, Ferain T, Hugenholtz J, Delcour J, de Vos WM
TitleConversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering.
[5]
PubMed ID11041346
JournalArch Microbiol
Year2000
Volume174
Pages162-7
AuthorsLaue H, Cook AM
TitlePurification, properties and primary structure of alanine dehydrogenase involved in taurine metabolism in the anaerobe Bilophila wadsworthia.


createdupdated
2004-03-162009-09-28


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2010)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)

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