|
|
| CATH domain | Related DB codes (homologues) |
|---|
| 3.40.50.150 | S00637,S00639,S00262,S00261,S00291,S00412,D00076,D00079,D00080,D00082,D00083,D00823 |
| Enzyme Name | | Swiss-prot | KEGG |
|---|
| P13255 |
|---|
| Protein name | Glycine N-methyltransferase | glycine N-methyltransferaseglycine methyltransferaseS-adenosyl-L-methionine:glycine methyltransferaseGNMT |
|---|
| Synonyms | EC 2.1.1.20Folate-binding protein |
|---|
| KEGG pathways | | MAP code | Pathways |
|---|
| MAP00260 | Glycine, serine and threonine metabolism |
| Swiss-prot:Accession Number | P13255 |
|---|
| Entry name | GNMT_RAT |
|---|
| Activity | S-adenosyl-L-methionine + glycine = S- adenosyl-L-homocysteine + sarcosine. |
|---|
| Subunit | Homotetramer. |
|---|
| Subcellular location | Cytoplasm. |
|---|
| Cofactor |
|
|---|
| References for Catalytic Mechanism | | References | Sections | No. of steps in catalysis |
|---|
| [2] | Fig.9, p.11992-11993 | 2 | | [3] | Fig.6, p.21 | 2 | | [7] | Fig.6, p.8399-8401 |
|
| references | | [1] |
|---|
| PubMed ID | 7734248 |
|---|
| Journal | J Struct Biol |
|---|
| Year | 1994 |
|---|
| Volume | 113 |
|---|
| Pages | 247-9 |
|---|
| Authors | Fu Z, Takusagawa F, Konishi K, Takata Y, Fujioka M |
|---|
| Title | Crystallization and preliminary X-ray diffraction studies of glycine methyltransferase from rat liver. |
|---|
| [2] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) |
|---|
| Medline ID | 96406816 |
|---|
| PubMed ID | 8810903 |
|---|
| Journal | Biochemistry |
|---|
| Year | 1996 |
|---|
| Volume | 35 |
|---|
| Pages | 11985-93 |
|---|
| Authors | Fu Z, Hu Y, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F |
|---|
| Title | Crystal structure of glycine N-methyltransferase from rat liver. |
|---|
| Related PDB | 1xva |
|---|
| Related Swiss-prot | P13255 |
|---|
| [3] |
|---|
| PubMed ID | 9597750 |
|---|
| Journal | Int J Biochem Cell Biol |
|---|
| Year | 1998 |
|---|
| Volume | 30 |
|---|
| Pages | 13-26 |
|---|
| Authors | Ogawa H, Gomi T, Takusagawa F, Fujioka M |
|---|
| Title | Structure, function and physiological role of glycine N-methyltransferase. |
|---|
| [4] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) |
|---|
| Medline ID | 98318042 |
|---|
| PubMed ID | 9655336 |
|---|
| Journal | Protein Sci |
|---|
| Year | 1998 |
|---|
| Volume | 7 |
|---|
| Pages | 1326-31 |
|---|
| Authors | Pattanayek R, Newcomer ME, Wagner C |
|---|
| Title | Crystal structure of apo-glycine N-methyltransferase (GNMT). |
|---|
| Related PDB | 1bhj |
|---|
| Related Swiss-prot | P13255 |
|---|
| [5] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) |
|---|
| PubMed ID | 10756111 |
|---|
| Journal | J Mol Biol |
|---|
| Year | 2000 |
|---|
| Volume | 298 |
|---|
| Pages | 149-62 |
|---|
| Authors | Huang Y, Komoto J, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F |
|---|
| Title | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. |
|---|
| Related PDB | 1d2c,1d2g,1d2h |
|---|
| Related Swiss-prot | P13255 |
|---|
| [6] |
|---|
| PubMed ID | 12079381 |
|---|
| Journal | J Mol Biol |
|---|
| Year | 2002 |
|---|
| Volume | 320 |
|---|
| Pages | 223-35 |
|---|
| Authors | Komoto J, Huang Y, Takata Y, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F |
|---|
| Title | Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase. |
|---|
| [7] |
|---|
| PubMed ID | 12859184 |
|---|
| Journal | Biochemistry |
|---|
| Year | 2003 |
|---|
| Volume | 42 |
|---|
| Pages | 8394-402 |
|---|
| Authors | Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F |
|---|
| Title | Catalytic mechanism of glycine N-methyltransferase. |
|---|
| Related PDB | 1nbh,1nbi |
|---|
| created | updated |
|---|
| 2004-03-17 | 2009-02-26 |
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