EzCatDB: M00007

DB codeM00007
CATH domainDomain 13.40.50.740
Domain 23.40.228.10Catalytic domain
Domain 33.90.55.10
Domain 42.40.40.20
E.C.1.7.2.3
CSA1tmo

CATH domainRelated DB codes (homologues)
2.40.40.20S00101

Enzyme Name
Swiss-protKEGG

O87948
Protein nameTrimethylamine-N-oxide reductasetrimethylamine-N-oxide reductase (cytochrome c)
TMAO reductase
TOR
SynonymsTMAO reductase
Trimethylamine oxidase
EC 1.7.2.3


Swiss-prot:Accession NumberO87948
Entry nameTORA_SHEMA
ActivityTrimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+).
Subunit
Subcellular locationPeriplasm.
Cofactor


CofactorsSubstratesProducts
KEGG-idC00150C00126C01104C00080C00125C00565C00001
CompoundMolybdenumFerrocytochrome cTrimethylamine N-oxideH+Ferricytochrome cTrimethylamineH2O
Typeheavy metalamide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide groupamine groupothersamide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide groupamine groupH2O
1tmoA01UnboundUnboundUnbound
UnboundUnbound
1tmoA02Bound:2MOUnboundUnbound
UnboundUnbound
1tmoA03UnboundUnboundUnbound
UnboundUnbound
1tmoA04UnboundUnboundUnbound
UnboundUnbound

Active-site residues
resource
PDB;1tmo
pdbCofactor-binding residues
1tmoA01
1tmoA02SER 149 (Molybdenum binding)
1tmoA03
1tmoA04


references
[1]
CommentsX-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
Medline ID99033057
PubMed ID9813128
JournalJ Mol Biol
Year1998
Volume284
Pages435-47
AuthorsCzjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R
TitleCrystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution.
Related PDB1tmo
Related Swiss-protO87948
[2]
PubMed ID11781311
JournalJ Biol Chem
Year2002
Volume277
Pages10362-6
AuthorsAllen SC, Barrett CM, Ray N, Robinson C
TitleEssential cytoplasmic domains in the Escherichia coli TatC protein.


createdupdated
2004-03-252009-02-26
Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2010)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)

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