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| Medline ID | 90219023 |
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| PubMed ID | 2157850 |
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| Year | 1990 |
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| Title | Solution structure of the kringle 4 domain from human plasminogen by 1H nuclear magnetic resonance spectroscopy and distance geometry. |
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| Related Swiss-prot | P00747 |
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| Comments | X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 374-461. |
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| Medline ID | 92031502 |
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| Authors | Mulichak AM, Tulinsky A, Ravichandran KG |
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| Title | Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution. |
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| Related PDB | 1pk4 |
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| Related Swiss-prot | P00747 |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 374-461. |
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| Medline ID | 92031503 |
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| PubMed ID | 1657149 |
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| Journal | Biochemistry |
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| Year | 1991 |
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| Volume | 30 |
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| Pages | 10589-94 |
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| Title | The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4. |
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| Related PDB | 2pk4 |
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| Related Swiss-prot | P00747 |
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| PubMed ID | 1847112 |
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| Journal | FEBS Lett |
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| Year | 1991 |
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| Volume | 278 |
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| PubMed ID | 1827215 |
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| Year | 1991 |
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| Pages | 255-61 |
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| PubMed ID | 8218159 |
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| Journal | Biochemistry |
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| Year | 1993 |
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| Volume | 32 |
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| Pages | 10936-43 |
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| Authors | Hoover GJ, Menhart N, Martin A, Warder S, Castellino FJ |
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| Title | Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with omega-amino acids. |
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| Comments | X-ray crystallography |
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| PubMed ID | 8054447 |
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| Journal | Blood Coagul Fibrinolysis |
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| Year | 1994 |
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| Volume | 5 |
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| Pages | 157-66 |
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| Authors | Wu TP, Padmanabhan KP, Tulinsky A |
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| Title | The structure of recombinant plasminogen kringle 1 and the fibrin binding site. |
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| Related PDB | 1pkr |
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| PubMed ID | 8187244 |
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| Journal | Chem Phys Lipids |
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| Year | 1994 |
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| Volume | 67-68 |
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| Pages | 43-58 |
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| Authors | Cox M, Schaller J, Boelens R, Kaptein R, Rickli E, Llinas M |
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| Title | Kringle solution structures via NMR: two-dimensional 1H-NMR analysis of horse plasminogen kringle 4. |
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| Comments | STRUCTURE BY NMR OF 96-184. |
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| Medline ID | 94237158 |
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| PubMed ID | 8181476 |
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| Journal | Eur J Biochem |
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| Year | 1994 |
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| Volume | 221 |
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| Pages | 939-49 |
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| Authors | Rejante MR, Llinas M |
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| Title | Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1. |
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| Related PDB | 1hpj,1hpk |
|---|
| Related Swiss-prot | P00747 |
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| [31] |
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| Comments | STRUCTURE BY NMR OF 96-184. |
|---|
| Medline ID | 94237157 |
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| PubMed ID | 8181475 |
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| Journal | Eur J Biochem |
|---|
| Year | 1994 |
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| Volume | 221 |
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| Pages | 927-37 |
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| Authors | Rejante MR, Llinas M |
|---|
| Title | 1H-NMR assignments and secondary structure of human plasminogen kringle 1. |
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| Related Swiss-prot | P00747 |
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| [32] |
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| Comments | X-ray crystallography |
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| PubMed ID | 8069221 |
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| Journal | Protein Sci |
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| Year | 1994 |
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| Volume | 3 |
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| Pages | 898-910 |
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| Authors | Padmanabhan K, Wu TP, Ravichandran KG, Tulinsky A |
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| Title | Kringle-kringle interactions in multimer kringle structures. |
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| Related PDB | 1pmk |
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| [33] |
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| PubMed ID | 7793622 |
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| Journal | Anal Biochem |
|---|
| Year | 1995 |
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| Volume | 226 |
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| Pages | 225-31 |
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| Authors | Castro MJ, Kingston IB, Anderson S |
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| Title | A spectrophotometric assay for the determination of the catalytic efficiency of plasminogen activators using a slowly hydrolyzed plasmin substrate. |
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| PubMed ID | 7711052 |
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| Journal | Biochim Biophys Acta |
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| Year | 1995 |
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| Volume | 1248 |
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| Pages | 1-10 |
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| Authors | Rudd PM, Woods RJ, Wormald MR, Opdenakker G, Downing AK, Campbell ID, Dwek RA |
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| Title | The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator. |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 102-181. |
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| Medline ID | 96180681 |
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| PubMed ID | 8611560 |
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| Journal | Biochemistry |
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| Year | 1996 |
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| Volume | 35 |
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| Pages | 2567-76 |
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| Authors | Mathews II, Vanderhoff-Hanaver P, Castellino FJ, Tulinsky A |
|---|
| Title | Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. |
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| Related PDB | 1cea,1ceb |
|---|
| Related Swiss-prot | P00747 |
|---|
| [36] |
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| Comments | STRUCTURE BY NMR OF 183-354. |
|---|
| Medline ID | 96194156 |
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| PubMed ID | 8652577 |
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| Journal | Biochemistry |
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| Year | 1996 |
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| Volume | 35 |
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| Pages | 2357-64 |
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| Authors | Sohndel S, Hu CK, Marti D, Affolter M, Schaller J, Llinas M, Rickli EE |
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| Title | Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains. |
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| Related Swiss-prot | P00747 |
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| [37] |
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| Comments | X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 376-454 |
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| Journal | Acta Crystallogr D Biol Crystallogr |
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| Year | 1997 |
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| Volume | 53 |
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| Pages | 169-78 |
|---|
| Authors | Stec B, Yamano A, Whitlow M, Teeter MM |
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| Title | Structure of Human Plasminogen Kringle 4 at 1.68 angstrom and 277 K. A Possible Structural Role of Disordered Residues. |
|---|
| Related PDB | 1krn |
|---|
| Related Swiss-prot | P00747 |
|---|
| [38] |
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| Comments | PHOSPHORYLATION SITE SER-597. |
|---|
| Medline ID | 97345939 |
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| PubMed ID | 9201958 |
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| Journal | Biochemistry |
|---|
| Year | 1997 |
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| Volume | 36 |
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| Pages | 8100-6 |
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| Authors | Wang H, Prorok M, Bretthauer RK, Castellino FJ |
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| Title | Serine-578 is a major phosphorylation locus in human plasma plasminogen. |
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| Related Swiss-prot | P00747 |
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| [39] |
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| Comments | X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 480-563. |
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| Medline ID | 98198034 |
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| PubMed ID | 9521645 |
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| Journal | Biochemistry |
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| Year | 1998 |
|---|
| Volume | 37 |
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| Pages | 3258-71 |
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| Authors | Chang Y, Mochalkin I, McCance SG, Cheng B, Tulinsky A, Castellino FJ |
|---|
| Title | Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. |
|---|
| Related PDB | 5hpg |
|---|
| Related Swiss-prot | P00747 |
|---|
| [40] |
|---|
| PubMed ID | 9563511 |
|---|
| Journal | FEBS Lett |
|---|
| Year | 1998 |
|---|
| Volume | 425 |
|---|
| Pages | 448-52 |
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| Authors | Takeda-Shitaka M, Umeyama H |
|---|
| Title | Elucidation of the cause for reduced activity of abnormal human plasmin containing an Ala55-Thr mutation: importance of highly conserved Ala55 in serine proteases. |
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| [41] |
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| Comments | X-ray crystallography |
|---|
| PubMed ID | 9783753 |
|---|
| Journal | Nat Struct Biol |
|---|
| Year | 1998 |
|---|
| Volume | 5 |
|---|
| Pages | 917-23 |
|---|
| Authors | Parry MA, Fernandez-Catalan C, Bergner A, Huber R, Hopfner KP, Schlott B, Guhrs KH, Bode W |
|---|
| Title | The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action. |
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| Related PDB | 1bui |
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| [42] |
|---|
| PubMed ID | 9761475 |
|---|
| Journal | Protein Sci |
|---|
| Year | 1998 |
|---|
| Volume | 7 |
|---|
| Pages | 1947-59 |
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| Authors | An SS, Marti DN, Carreno C, Albericio F, Schaller J, Llinas M |
|---|
| Title | Structural/functional properties of the Glu1-HSer57 N-terminal fragment of human plasminogen: conformational characterization and interaction with kringle domains. |
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| [43] |
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| Comments | X-ray crystallography |
|---|
| PubMed ID | 9733510 |
|---|
| Journal | Science |
|---|
| Year | 1998 |
|---|
| Volume | 281 |
|---|
| Pages | 1662-5 |
|---|
| Authors | Wang X, Lin X, Loy JA, Tang J, Zhang XC |
|---|
| Title | Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. |
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| Related PDB | 1bml |
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| [44] |
|---|
| Comments | NMR Structure |
|---|
| PubMed ID | 10625440 |
|---|
| Journal | Biochemistry |
|---|
| Year | 1999 |
|---|
| Volume | 38 |
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| Pages | 15741-55 |
|---|
| Authors | Marti DN, Schaller J, Llinas M |
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| Title | Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains. |
|---|
| Related PDB | 1b2i |
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| [45] |
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| Comments | X-ray crystallography |
|---|
| PubMed ID | 10460175 |
|---|
| Journal | Biochemistry |
|---|
| Year | 1999 |
|---|
| Volume | 38 |
|---|
| Pages | 11180-8 |
|---|
| Authors | Peisach E, Wang J, de los Santos T, Reich E, Ringe D |
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| Title | Crystal structure of the proenzyme domain of plasminogen. |
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| Related PDB | 1qrz |
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| [46] |
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| PubMed ID | 10390345 |
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| Journal | J Mol Biol |
|---|
| Year | 1999 |
|---|
| Volume | 290 |
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| Pages | 471-9 |
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| Authors | Jespers L, Lijnen HR, Vanwetswinkel S, Van Hoef B, Brepoels K, Collen D, De Maeyer M |
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| Title | Guiding a docking mode by phage display: selection of correlated mutations at the staphylokinase-plasmin interface. |
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| PubMed ID | 11076540 |
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| Journal | Biochemistry |
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| Year | 2000 |
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| Volume | 39 |
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| Pages | 13974-81 |
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| Authors | Boxrud PD, Bock PE |
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| Title | Streptokinase binds preferentially to the extended conformation of plasminogen through lysine binding site and catalytic domain interactions. |
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| [48] |
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| PubMed ID | 10769130 |
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| Journal | Biochemistry |
|---|
| Year | 2000 |
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| Volume | 39 |
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| Pages | 4740-5 |
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| Authors | Lin LF, Houng A, Reed GL |
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| Title | Epsilon amino caproic acid inhibits streptokinase-plasminogen activator complex formation and substrate binding through kringle-dependent mechanisms. |
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| [49] |
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| Comments | X-ray crystallography |
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| PubMed ID | 10656799 |
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| Journal | J Mol Biol |
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| Year | 2000 |
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| Volume | 295 |
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| Pages | 903-14 |
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| Authors | Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC |
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| Title | Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. |
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| Related PDB | 1ddj |
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| [50] |
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| PubMed ID | 10926513 |
|---|
| Journal | J Mol Biol |
|---|
| Year | 2000 |
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| Volume | 301 |
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| Pages | 333-47 |
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| Authors | Zajicek J, Chang Y, Castellino FJ |
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| Title | The effects of ligand binding on the backbone dynamics of the kringle 1 domain of human plasminogen. |
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| [51] |
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| PubMed ID | 11152303 |
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| Journal | J Pept Res |
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| Year | 2000 |
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| Volume | 56 |
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| Pages | 438-45 |
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| Authors | Schenone MM, Warder SE, Martin JA, Prorok M, Castellino FJ |
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| Title | An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen. |
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| [52] |
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| Comments | X-ray crystallography |
|---|
| PubMed ID | 11350170 |
|---|
| Journal | J Mol Biol |
|---|
| Year | 2001 |
|---|
| Volume | 308 |
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| Pages | 705-19 |
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| Authors | Rios-Steiner JL, Schenone M, Mochalkin I, Tulinsky A, Castellino FJ |
|---|
| Title | Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. |
|---|
| Related PDB | 1i5k |
|---|
| [53] |
|---|
| PubMed ID | 12080056 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2002 |
|---|
| Volume | 277 |
|---|
| Pages | 33068-74 |
|---|
| Authors | Turner RB, Liu L, Sazonova IY, Reed GL |
|---|
| Title | Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin. |
|---|
| [54] |
|---|
| Comments | X-ray crystallography |
|---|
| PubMed ID | 12054798 |
|---|
| Journal | J Mol Biol |
|---|
| Year | 2002 |
|---|
| Volume | 318 |
|---|
| Pages | 1009-17 |
|---|
| Authors | Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH |
|---|
| Title | The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. |
|---|
| Related PDB | 1ki0 |
|---|
| [55] |
|---|
| Comments | X-ray crystallography |
|---|
| PubMed ID | 12456874 |
|---|
| Journal | Protein Eng |
|---|
| Year | 2002 |
|---|
| Volume | 15 |
|---|
| Pages | 753-61 |
|---|
| Authors | Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC |
|---|
| Title | Effects of deletion of streptokinase residues 48-59 on plasminogen activation. |
|---|
| Related PDB | 1l4d |
|---|
| [56] |
|---|
| PubMed ID | 12515545 |
|---|
| Journal | Biochemistry |
|---|
| Year | 2003 |
|---|
| Volume | 42 |
|---|
| Pages | 114-20 |
|---|
| Authors | Zhai P, Wakeham N, Loy JA, Zhang XC |
|---|
| Title | Functional roles of streptokinase C-terminal flexible peptide in active site formation and substrate recognition in plasminogen activation. |
|---|
| [57] |
|---|
| PubMed ID | 12773528 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2003 |
|---|
| Volume | 278 |
|---|
| Pages | 30569-77 |
|---|
| Authors | Sundram V, Nanda JS, Rajagopal K, Dhar J, Chaudhary A, Sahni G |
|---|
| Title | Domain truncation studies reveal that the streptokinase-plasmin activator complex utilizes long range protein-protein interactions with macromolecular substrate to maximize catalytic turnover. |
|---|
| [58] |
|---|
| Comments | X-ray crystallography |
|---|
| PubMed ID | 15211511 |
|---|
| Journal | Proteins |
|---|
| Year | 2004 |
|---|
| Volume | 56 |
|---|
| Pages | 277-84 |
|---|
| Authors | Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC |
|---|
| Title | Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain. |
|---|
| Related PDB | 1rjx |
|---|
