EzCatDB: S00373

DB codeS00373
CATH domainDomain 13.40.50.1470Catalytic domain
E.C.3.1.1.29
CSA2pth


Enzyme Name
Swiss-protKEGG

P0A7D1
Protein namePeptidyl-tRNA hydrolaseaminoacyl-tRNA hydrolase
aminoacyl-transfer ribonucleate hydrolase
N-substituted aminoacyl transfer RNA hydrolase
peptidyl-tRNA hydrolase
SynonymsPTH
EC 3.1.1.29


Swiss-prot:Accession NumberP0A7D1
Entry namePTH_ECOLI
ActivityN-substituted aminoacyl-tRNA + H(2)O = N- substituted amino acid + tRNA.
SubunitMonomer.
Subcellular locationCytoplasm.
Cofactor


SubstratesProducts
KEGG-idC03880C00001C03523C00066
CompoundN-Substituted aminoacyl-tRNAH2ON-Substituted amino acidtRNA
Typeamino acids,amide group,nucleic acidsH2Oamino acids,amide groupnucleic acids
2pthAUnboundUnboundUnboundUnbound

Active-site residues
resource
literature [2],[3]
pdbCatalytic residues
2pthAASN 10;HIS 20;ASN 21;ASN 68;ASP 93;ASN 114


references
[1]
CommentsX-ray crystallography
PubMed ID9144799
JournalProteins
Year1997
Volume28
Pages135-6
AuthorsSchmitt E, Fromant M, Plateau P, Mechulam Y, Blanquet S
TitleCrystallization and preliminary X-ray analysis of Escherichia coli peptidyl-tRNA hydrolase.
Related Swiss-protP0A7D1
[2]
CommentsX-ray crystallography (1.2 Angstroms)
PubMed ID9303320
JournalEMBO J
Year1997
Volume16
Pages4760-9
AuthorsSchmitt E, Mechulam Y, Fromant M, Plateau P, Blanquet S
TitleCrystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.
Related PDB2pth
Related Swiss-protP0A7D1
[3]
PubMed ID10213600
JournalBiochemistry
Year1999
Volume38
Pages4982-7
AuthorsFromant M, Plateau P, Schmitt E, Mechulam Y, Blanquet S
TitleReceptor site for the 5'-phosphate of elongator tRNAs governs substrate selection by peptidyl-tRNA hydrolase.


createdupdated
2002-09-052009-02-26


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2010)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)

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